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KMID : 1007020030010010012
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Korean Soceity of Osteroporosis
2003 Volume.1 No. 1 p.12 ~ p.21
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A Study of Vitamin D Insufficiency in Postmenopausal Korean Women
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Kim Hoon
Ku Seung-Yup
Kim Seok-Hyun
Choi Young-Min
Moon Shin-Yong
Kim Jung-Gu
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Abstract
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Objectives: To evaluate the prevalence of vitamin D insufficiency and to investigate the relationship between bone mass and vitamin D status in Korean menopausal women
Methods: Serum 25(OH) vitamin D3, 1,25(OH)2 vitamin D3 and parathyroid hormone (PTH) were analyzed by radioimmunoassay in 378 menopausal women. Serum osteocalin, CrossLaps (CTX), and bone alkaline phosphatase(BAP) were measured by enzyme linked immunosorbent assay, and calcium and phosphorus by atomic absorptiometry. Bone mineral density(BMD) at the lumbar spine and proximal femur was measured by dual energy X-ray absorptiometry.
Results: The prevalence of vitamin D insufficiency [5≤25(OH) vitamin D3 ≤20ng/mL] was 22.2%. The prevalence of osteopenia-osteoporosis and serum PTH levels in vitamin D insufficiency group were significantly higher than those in normal vitamin D group, whereas there was no significant difference in BMD, and bone turnover markers including 1,25(OH)2 vitamin D3. Serum BAP levels were significantly higher in osteopenia-osteoporosis group than in normal BMD group but serum levels of 25(OH) vitamin D3, 1,25(OH)2 vitamin D3 and bone turnover markers were not different. Serum 25(OH) vitamin D3 was inversely related to PTH and calcium was positively related to PTH and 1,25(OH)2 vitamin D3.
Conclusion: Vitamin D insufficiency is observed in one fifth of postmenopausal Korean women. The prevalence of low bone mass in women with vitamin D insufficiency is higher, compared with normal healthy women.
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KEYWORD
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Vitamin D insufficienty, Bone mass, Bone marker
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